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Mechanical restriction of stomach volume refers to bariatric surgical or endoscopic interventions designed to physically limit the capacity of the stomach, thereby promoting weight loss by inducing early satiety and reducing food intake. Common methods include the placement of adjustable gastric bands, intragastric balloons, or surgical creation of a small gastric pouch (as in vertical banded gastroplasty or endoscopic sleeve gastroplasty). These interventions are frequently used in the management of obesity and related metabolic diseases. The mechanism of benefit is primarily through restricting meal volume, although hormonal and motility changes may contribute. Mechanical restriction itself is not a molecular or drug target, but rather a clinical or procedural intervention category[3].
Physical reduction of gastric capacity to induce early fullness, limit meal size, slow gastric emptying, and support caloric restriction; effects on gut hormones are secondary and not fully understood[3]
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