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Target intelligence / Profile preview
Mechanistic Target of Rapamycin Kinase Complex 1 (mTORC1)
- Target
- mTORC1
- Molecular classification
- Multi-protein complex, Kinase complex
01
Overview
mTORC1 is a multi-protein complex that functions as a central regulator of cell growth, metabolism, proliferation, and survival. It acts as an intracellular sensor integrating signals from nutrients, energy status, growth factors, hormones, amino acids, and glucose to control anabolic processes such as protein synthesis and lipid biosynthesis. mTORC1 is acutely sensitive to inhibition by the drug rapamycin.
- Other names
- Mammalian Target of Rapamycin Complex 1
02
Mechanism of action
Allosteric inhibition of mTORC1 activity
03
Biological functions
Cell growth regulationMetabolism regulationProliferation regulationSurvival regulationProtein synthesis regulationLipid biosynthesis regulationAutophagy regulation
04
Disease associations
CancerMetabolic disordersDiabetesObesityNeurodegenerative diseaseCardiovascular disease
05
Safety considerations
Immunosuppression
06
Interacting drugs
Rapamycin
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