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Target intelligence / Profile preview
Mechanistic Target of Rapamycin Signaling Pathway (mTOR)
- Target
- mTOR
- Molecular classification
- Signaling pathway, Serine/threonine kinase, Enzyme
01
Overview
The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that serves as a central regulator of cell growth, metabolism, proliferation, survival, and autophagy. It integrates signals from nutrients, growth factors, energy status, and cellular stress to coordinate anabolic and catabolic processes. It exists in two distinct complexes, mTORC1 and mTORC2, with differing functions and sensitivities to rapamycin.
- Other names
- Mammalian Target of Rapamycin Signaling PathwaymTOR pathway
02
Mechanism of action
Inhibition of mTORC1 and/or mTORC2 kinase activity
03
Biological functions
Cell growth/proliferation controlMetabolism regulationSuppression of autophagyProtein synthesisLipid biosynthesisNucleotide synthesisCell survivalRegulation of cytoskeleton
04
Disease associations
CancerCardiovascular diseaseDiabetes mellitus type IIMetabolic disease
05
Safety considerations
ImmunosuppressionMetabolic disturbancesWound healing impairment
06
Interacting drugs
Rapamycin
2 more in the full profile.
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