Mediator complex subunit 12-like protein (MED12L)

Mediator complex subunit 12-like protein (MED12L) is a subunit of the Mediator kinase module, a multi-protein complex that acts as a coactivator for RNA polymerase II-dependent transcription in almost all eukaryotes[1][2][5]. As part of this module, MED12L helps relay signals from gene-specific regulators to the basal transcription machinery and is important for the regulation of gene expression during development, especially in the nervous system[1][5]. Genetic variants causing loss of function in MED12L are associated with intellectual disability, developmental delay, and speech impairment, sometimes accompanied by behavioral abnormalities and mild facial differences[1]. MED12L is highly expressed in the brain and is predicted to share domain homology with MED12, including roles in Wnt/beta-catenin pathway activation[1]. While key to fundamental transcriptional processes, MED12L is not currently considered a therapeutic target or site of known drug interaction[1][5].

Other names

Mediator of RNA polymerase II transcription subunit 12-like proteinKIAA1635TNRC11LTRALPTRALPUSHPRO0314Mediator complex subunit 12-like proteinThyroid hormone receptor-associated-like proteinTrinucleotide repeat-containing gene 11 protein-likeNIZIDSNOPARNo opposite paired repeat protein