Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mediator complex subunit 16 (MED16)
- Target
- MED16
- Molecular classification
- Transcription coactivator, Mediator complex subunit, Other (structural/regulatory subunit of a multiprotein complex; not a classical receptor, enzyme, etc.)
01
Overview
Mediator complex subunit 16 (MED16) is a protein located in the nucleus, where it forms part of the multi-subunit Mediator complex. This complex is a crucial transcriptional coactivator, connecting sequence-specific transcription factors to the RNA polymerase II machinery, thereby regulating the initiation of transcription for most protein-coding genes in eukaryotes. MED16 does not possess catalytic activity but contributes to the structural and functional integrity of the Mediator complex, affecting the expression of specific gene regulons in processes such as development, stress responses, and hormone signaling. In humans, mutations in MED16 are associated with certain intellectual disability syndromes.
- Other names
- MED16Sur2 (in yeast)Med16 homolog (human ortholog)
02
Mechanism of action
Not applicable for direct targeting; MED16 conveys regulatory signals from transcription factors to the transcription preinitiation complex as a scaffold component
03
Biological functions
Regulation of transcription initiation by RNA polymerase IIBridge between gene-specific transcription factors and basal transcription machineryNuclear thyroid hormone receptor binding
04
Disease associations
Syndromic intellectual disabilityGuillouet-Gordon syndromeOther (potential roles in gene regulation networks in human disease; direct involvement as a target is not established)
05
Safety considerations
Potential for broad effects on gene expression if dysregulated, leading to developmental or systemic transcriptional abnormalitiesNot considered for therapeutic modulation due to these broad essential functions
Beyond the preview
Go deeper on Mediator complex subunit 16 (MED16).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mediator complex subunit 16 (MED16).