Mediator complex subunit 24 (MED24)

Mediator complex subunit 24 (MED24) is a component of the multi-protein Mediator complex, which enables the transcription of protein-coding genes by bridging regulatory elements and the RNA polymerase II enzyme. MED24 is classified as part of the "tail" module of the complex, and is essential for integration of cell signaling pathways (such as FGF/ERK) and nuclear receptor signaling (e.g. estrogen receptor, vitamin D receptor) in embryonic stem cells and other cell types. Loss of MED24 disrupts differentiation and cell fate decisions by impairing the transcriptional response to signaling cues. MED24 is highly conserved across eukaryotes and functions as a coactivator in a range of tissues and developmental processes. It is implicated in cancer and developmental disorders associated with abnormal gene regulation.

Other names

ARC100CRSP4DRIP100KIAA0130THRAP4TRAP100CRSP complex subunit 4Trap100hTRAP100CRSP100MED5Activator-recruited cofactor 100 kDa componentCofactor required for Sp1 transcriptional activation subunit 4Thyroid hormone receptor-associated protein 4Vitamin D3 receptor-interacting protein complex 100 kDa component

Drugs (e.g. hormone analogs) acting upstream on nuclear receptors can modulate the gene expression by influencing Mediator complex recruitment, including MED24’s involvement.