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Mediator complex subunit 27 pseudogene

Molecular classification
Pseudogene
01

Overview

This entry appears to be problematic as it refers to a pseudogene rather than a functional therapeutic target. The search results describe MED27 (mediator complex subunit 27), which is a functional protein-coding gene that encodes a component of the Mediator complex involved in RNA polymerase II transcription regulation. The actual MED27 gene is located on chromosome 9 and plays important roles in transcriptional activation by serving as a subunit of the CRSP (cofactor required for SP1 activation) complex. However, the search results mention that "a pseudogene of this gene is located on the long arm of chromosome 5". Pseudogenes are non-functional gene copies that typically cannot produce functional proteins and are therefore not considered therapeutic targets. The identifier ENSG00000248569 likely refers to this non-functional pseudogene copy rather than the active MED27 gene, making it unsuitable as a therapeutic target.

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