Mediator complex subunit 29 (MED29)

Mediator complex subunit 29 (MED29) is a component of the multi-protein Mediator complex, which serves as a central coactivator that conveys regulatory signals from DNA-bound transcription factors to the general transcriptional machinery including RNA polymerase II[4][5]. MED29 functions primarily as a structural and regulatory element within the Mediator tail module and participates in modulating RNA polymerase II-dependent gene expression[2][4][5]. MED29 has dualistic roles in cancer, acting as both an oncogene and tumor suppressor in pancreatic cancer depending on the cellular context, where its altered expression can affect cell proliferation, migration, invasion, and cell cycle progression[1]. It also appears to modulate germ cell proliferation and apoptosis in model organisms, such as _C. elegans_, indicating broader roles in developmental and homeostatic gene regulation[3]. MED29 is not itself a typical therapeutic target (like a receptor, enzyme, or transporter), but dysregulation of its function or expression is linked to disease processes including cancer and rare skin syndromes[1][4].

Other names

Mediator of RNA polymerase II transcription subunit 29IXLDKFZp434H247MED2Intersex-like protein