Mediator Kinase Module (CKM)

The Mediator kinase module (CKM), primarily consisting of CDK8 or CDK19 along with MED12, MED13, and Cyclin C, is a key regulator of RNA polymerase II activity and gene expression. It integrates extracellular signals, including those from the Wnt pathway, to modulate transcriptional responses. It phosphorylates various targets to fine-tune gene expression, making it a potential therapeutic target in cancers like colorectal carcinoma driven by aberrant Wnt signaling.

Other names

CDK8 moduleCDK19 moduleMediator CDK8/CDK19 complexKinase mediator of the Wnt pathway

Phosphorylation of transcription factors, RNA polymerase II, and chromatin modifiers to regulate gene expression downstream of Wnt signaling and other pathways.