Mediator of RNA polymerase II transcription subunit 14 (MED14)

Mediator of RNA polymerase II transcription subunit 14 (MED14) is a large scaffolding protein that acts as a crucial architectural and functional backbone of the Mediator complex, an evolutionarily conserved multiprotein complex required for regulated transcription of nearly all RNA polymerase II-dependent genes. MED14 bridges the head, middle, and tail modules of the Mediator, facilitating structural integrity, and is critical for both basal and activator-dependent (e.g., p53) transcription. Its interaction with RNA polymerase II is essential for transcription initiation. MED14 also associates with general transcription factors, nuclear receptors, and certain cofactors including CRSP and thyroid hormone receptor complexes. Mutations or dysregulation of MED14 may have a role in cancer and other disorders of transcription, but it is not a direct therapeutic target, biomarker, or druggable protein as of current knowledge[1][2][4][6][7].

Other names

ARC150CRSP2CXorf4DRIP150EXLM1RGR1TRAP170CRSP complex subunit 2hRGR1CSRPActivator-recruited cofactor 150 kDa componentCofactor required for Sp1 transcriptional activation subunit 2RGR1 homologThyroid hormone receptor-associated protein complex 170 kDa componentTranscriptional coactivator CRSP150Vitamin D3 receptor-interacting protein complex 150 kDa component