Mediator of RNA polymerase II transcription subunit 6 (MED6)

Mediator of RNA polymerase II transcription subunit 6 (MED6) is a highly conserved protein that is a core component of the Mediator complex, an essential multi-subunit coactivator that regulates transcription of nearly all RNA polymerase II-dependent genes in eukaryotes[4][7]. MED6 functions as a critical interface between the head and middle modules of Mediator, relaying regulatory signals from transcriptional activators to the core transcriptional machinery[1][5]. It is essential for conformational changes and the functioning of the Mediator complex during transcriptional activation, and its disruption impairs the postrecruitment steps of gene activation[1][3][5]. Mutations in key domains of MED6 abolish cell viability in model organisms, highlighting its importance in gene expression regulation. While MED6 has aliases linked to cancer antigens (e.g., NY-REN-28), current data suggest it is fundamentally a structural and regulatory transcriptional coactivator, not a direct druggable target or receptor[7].

Other names

ARC33hMed6NY-REN-28Activator-recruited cofactor 33 kDa componentRenal carcinoma antigen NY-REN-28CTD-2540L5.5