Medium-wave-sensitive opsin 1 (OPN1MW)

Medium-wave-sensitive opsin 1 (OPN1MW) is a member of the opsin family of G protein-coupled receptors, functioning as the photopigment in retinal cone cells responsible for detecting green/yellow light (middle of the visible spectrum)[1][2][4][6]. It is located on the X chromosome and is essential for normal color vision, enabling signal transmission from cone cells to the brain for the perception of color[1][2][6]. Mutations or structural rearrangements of the OPN1MW gene lead to several hereditary vision disorders—including the common deutan type of red-green color vision deficiency and rare forms such as cone dystrophy 5 (X-linked) and blue cone monochromacy[1][2][4]. The protein consists of seven transmembrane domains typical of GPCRs, binding covalently to a cis-retinal chromophore [2][3][6]. OPN1MW is not a current target for approved pharmacological interventions, but genetic tests can identify relevant mutations for clinical and diagnostic purposes[1][5].

Other names

Green cone photoreceptor pigmentGreen-sensitive opsinGreen cone pigmentOPN1MW1GCPGOPCBBMCBDM-pigmentMiddle-wave-sensitive pigmentOPSG_HUMANPhotopigment apoprotein