Medium-wave-sensitive opsin 3 (OPN1MW3)

Medium-wave-sensitive opsin 3 (OPN1MW3) is a photopigment protein and member of the G protein-coupled receptor family, specifically expressed in cone photoreceptor cells of the retina that are responsible for detecting light in the middle wavelengths (green/yellow spectrum)[1][2][3]. It is one of several paralogs of the OPN1MW gene cluster on chromosome X and encodes an opsin protein that binds a retinal chromophore to enable color discrimination and light perception[1][5]. Mutations or rearrangements involving OPN1MW/OPN1MW3 cause X-linked red-green color vision deficiencies (deuteranopia, deuteranomaly), cone dystrophies, and are implicated in age-related macular degeneration[1][2][3]. OPN1MW3 is not considered a therapeutic drug target in current clinical use, and there are no marketed drugs designed to modulate its function. Notes on accuracy and conventions: - OPN1MW3 is not a commonly recognized or distinct clinical/therapeutic target; the canonical gene for human green opsin is OPN1MW. - OPN1MW3 is sometimes listed as a paralog or pseudogene, and most clinical/disease literature refers to OPN1MW, not OPN1MW3[2][3][5]. - The listing of OPN1MW3 is likely due to complex genomic arrangements and multiple gene copies; consequently, the “is_incorrect” flag is set to true because OPN1MW3 is not a standard, distinct therapeutic target and most validated functional disease associations reference the OPN1MW gene[1][2][3].

Other names

Medium-wave-sensitive opsin 3Green cone photoreceptor pigmentGreen-sensitive opsinGOPOpsin 1 cone pigments medium-wave-sensitive 3GCPOPN1MWOPN1MW2OPN1MW1M-pigmentphotopigment apoproteingreen cone pigmentmiddle-wave-sensitive pigmentOPSG_HUMAN

N/A (no known drugs targeting OPN1MW3 directly; general opsins interact with cis-retinal as chromophore for vision)