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MEF2-activating motif and SAP domain-containing transcriptional regulator (MAMSTR)
- Target
- MAMSTR
- Molecular classification
- Transcription factor, Transcriptional coactivator
01
Overview
MEF2-activating motif and SAP domain-containing transcriptional regulator (MAMSTR) is a member of the myocardin-related transcriptional coactivators that functions as a key facilitator of MEF2 (myocyte enhancer factor 2)-dependent gene expression, particularly in skeletal muscle. MAMSTR acts as a transcriptional coactivator, directly interacting with MEF2 proteins to activate muscle-specific enhancers and promote the expression of regulators such as MyoD[1][6][7]. Inhibition of MAMSTR impairs myoblast differentiation and muscle regeneration, highlighting its critical role in myogenesis and satellite cell function[1]. MAMSTR is predicted to act primarily in the nucleus, with additional roles in the broader regulation of transcription by RNA polymerase II[5]. While not a traditional therapeutic target like receptors or enzymes, MAMSTR's function in muscle biology has implications for regenerative medicine and livestock genetic traits[1].
- Other names
- MASTRMEF2 activating motif and SAP domain containing transcriptional regulatorFLJ36070MEF2-activating SAP transcriptional regulatory proteinMEF2-activating SAP transcriptional regulator
02
Biological functions
Regulation of transcription by RNA polymerase IIPositive regulation of myotube differentiationPositive regulation of transcriptionActivation of MEF2-dependent gene expressionSkeletal muscle differentiation and regeneration
03
Disease associations
Other (No direct evidence for established disease associations, but roles in muscle regeneration and defects suggest relevance for muscle disorders/regeneration)
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