Meibomian gland ductal obstruction

"Meibomian gland ductal obstruction relief by physical expression" is not a molecular target, receptor, enzyme, or protein. Instead, it refers to a **therapeutic procedure** used to treat obstructive meibomian gland dysfunction (MGD), which is the most common cause of evaporative dry eye disease. The procedure involves physically expressing the contents of blocked meibomian glands—either manually or using devices—sometimes in combination with heat therapy. This mechanical intervention aims to clear obstructions within the ducts of the meibomian glands, restore normal oil flow into the tear film, stabilize tear film quality, and relieve symptoms such as ocular irritation and dryness[1][2][4][8]. Physical expression can be performed alone or after other treatments like warm compresses or vectored thermal pulsation systems (e.g., LipiFlow). More advanced techniques include **meibomian gland probing**, which uses a fine probe to mechanically open blocked ducts under local anesthesia[1][2]. These interventions are often combined with medical therapies such as topical antibiotics (azithromycin), oral antibiotics (doxycycline), corticosteroids for inflammation control, and at-home lid hygiene regimens[5][7]. This entry is not a canonical molecular target but rather describes a clinical intervention for an anatomical/functional abnormality; therefore, **is_incorrect** should be set to true. > "Manual expression...involves applying pressure to the eyelids to express oil from the glands. Successful meibomian gland expression helps increase the quality of oil production...and decrease dry eye." [8] > "Meibomian gland probing...has emerged as a pivotal intervention in managing obstructive MGD...[it] uses a wired probe to remove obstructions through natural orifices..." [1] In summary: this term does not refer to any specific molecule/receptor/protein but rather describes an interventional approach for treating an anatomical blockage in eyelid glands.

Other names

Meibomian gland obstructionObstructive meibomian gland dysfunction (OMGD)MGD with ductal blockage

Anti-inflammatory action (for antibiotics and corticosteroids)