Meiosis regulator and mRNA stability factor 1 (MARF1)

Meiosis regulator and mRNA stability factor 1 (MARF1) is an essential RNA-binding protein required for normal oocyte maturation, meiotic progression, and maintenance of genome integrity in female germ cells. It includes an NYN ribonuclease domain and multiple LOTUS domains, which are involved in post-transcriptional mRNA regulation, particularly deadenylation and silencing of target transcripts such as cyclin A mRNA. MARF1 functions by binding to specific mRNAs and recruiting the CCR4-NOT deadenylase complex to shorten their poly-A tails, suppress translation, and reduce protein levels, which is critical for proper cell cycle progression during oogenesis. In addition, MARF1 suppresses transposable element activity and prevents DNA damage, contributing to genomic stability. It also appears as a component of cellular P-bodies involved in mRNA turnover in various cell types, including immune cells. Mutations in MARF1 cause female infertility due to defects in meiotic progression and transposon surveillance. Key molecular features include: Contains NYN ribonuclease domain, RNA-recognition motif (RRM), and several LOTUS domains for mRNA binding and protein-protein interactions. Regulates the polyadenylation status and stability of mRNAs, silencing cyclin A and other mRNAs critical for oocyte maturation. Acts as a functional analog of nuage-associated proteins in the female germline, executing meiosis regulation and genome protection. Expressed predominantly in oocytes but also in immune cell lines. No established pharmacological modulators (drugs); experimental models connect deficiency to infertility and, rarely, autoimmune responses.

Other names

KIAA0430LKAPPPP1R34LMKBLimkain-b1Meiosis arrest female protein 1meiosis arrest female 1protein phosphatase 1, regulatory subunit 34

Not applicable (no drugs established); mechanistic studies indicate MARF1 modulates mRNA decay, retrotransposon silencing, and oocyte maturation via ribonuclease activity and recruitment of the CCR4-NOT deadenylase complex.