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Target intelligence / Profile preview
meiosis regulator for oocyte development (MIOS)
- Target
- MIOS
- Molecular classification
- Other (GATOR2 complex protein, WD repeat-containing protein)
01
Overview
Meiosis regulator for oocyte development (MIOS) is a protein-coding gene, highly conserved, and a component of the GATOR2 complex, which is involved in the regulation of the mTORC1 pathway in response to amino acid availability[2][3]. It plays roles in cellular response to amino acid starvation, localization of protein complexes, and has a positive regulatory effect on TOR signaling. Although its name implies involvement in oocyte meiosis regulation, functional annotation in human and mouse points to broader roles in cell growth and metabolic regulation[1][2][3][4]. There are currently no approved drugs targeting MIOS, nor is MIOS established as a therapeutic target. Its molecular family is best described as a WD repeat-containing protein and a component of multiprotein regulatory complexes[2].
- Other names
- WD repeat-containing protein mioMIOSea4YulinkMissing oocyte meiosis regulator homologFLJ20323H_DJ1159O04.1WUGSC:H_DJ1159O04.1RGD1308432
02
Biological functions
Cellular response to amino acid starvationPositive regulation of TOR signalingProtein-containing complex localizationInvolved in oocyte and possibly neural development
03
Disease associations
Other (no direct disease association reported in major databases as of the information retrieved)
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