Meiotic nuclear division protein 1 homolog (MND1)

Meiotic nuclear division protein 1 homolog (MND1) is a highly conserved eukaryotic protein necessary for proper homologous chromosome pairing and the resolution of meiotic double-strand breaks. In mammals, the MND1 protein forms a stable heterodimeric complex with Hop2. This complex binds both DNA and recombinase proteins (Dmc1, Rad51), stimulating their activity to drive strand invasion and cross-over events during the meiotic recombination process. Structurally, MND1 contains a winged-helix DNA-binding domain and several coiled-coil leucine zipper regions that facilitate dimerization and protein interactions. Loss of MND1 function causes severe defects in meiosis, resulting in infertility conditions such as primary ovarian insufficiency and azoospermia. MND1 is not typically regarded as a druggable therapeutic target and has limited clinical biomarker value, but is crucial for germline genome integrity.

Other names

Meiotic nuclear divisions 1MND1GAJMeiotic nuclear division protein 1 homologHomolog of yeast MND1

Not applicable (no drugs are known to target MND1 directly)