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Target intelligence / Profile preview
Meiotic Recombination 11 Endo-exonuclease (None)
- Target
- None
- Molecular classification
- Enzyme, Nuclease, Exonuclease, Endonuclease
01
Overview
MRE11 is a highly conserved nuclease with both endonuclease and exonuclease activities, playing a central role in maintaining genome stability. It is a core component of the MRN complex (MRE11-RAD50-NBS1), essential for DNA double-strand break (DSB) repair, DNA replication, checkpoint signaling, homologous recombination, and telomere maintenance. Mutations or dysregulation in *MRE11* are linked to cancer predisposition syndromes due to impaired DSB repair capacity, affecting sensitivity/resistance to chemotherapeutics like gemcitabine.
02
Mechanism of action
MRE11's endonuclease activity creates nicks near break sites, followed by its 3' to 5' exonuclease activity resecting DNA toward the break, which is essential for homologous recombination initiation. It also removes chain terminators like gemcitabine from nascent DNA during replication.
03
Biological functions
DNA double-strand break (DSB) repairDNA replicationCheckpoint signalingHomologous recombinationTelomere maintenanceCell cycle control
04
Disease associations
CancerCancer predisposition
05
Safety considerations
Increased sensitivity to ionizing radiationDefective DSB repair pathways leading to genomic instability
06
Interacting drugs
Gemcitabine
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