Meiotic recombination protein REC8 homolog (REC8)

Meiotic recombination protein REC8 homolog (REC8) is a meiosis-specific component of the cohesin complex, encoded by the human REC8 gene. It binds sister chromatids and is essential for their cohesion during both divisions of meiosis[1]. REC8 localizes to chromosome axes during meiosis, forming structural scaffolds necessary for the synaptonemal complex and proper homologous recombination[3]. Its removal from chromosome arms in meiosis I enables homologous chromosomes to separate, while retention at centromeres maintains sister chromatid cohesion until anaphase II[1]. REC8 partners with other cohesin proteins (STAG3, SMC1B, SMC3) to regulate chromatid cohesion and recombination. Disruption leads to improper chromosome pairing, meiotic errors, and sterility[3]. REC8 is not a therapeutic target (such as a receptor, enzyme, or transporter), but is fundamental for meiotic chromosome dynamics and fertility[1][3][4].

Other names

HR21SPBREC8PREC8L1Rec8pkleisin-alphacohesin Rec8phuman homolog of rad21meiotic recombination protein REC8-like 1cohesion rec8pS. pombe Rec8meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p familyrecombination and sister chromatid cohesion protein homolog

null