Meis homeobox 3 pseudogene 2 (MEIS3P2)

Meis homeobox 3 pseudogene 2 (MEIS3P2) is classified as a pseudogene of the homeobox-containing MEIS gene family, specifically related to the MEIS3 gene[1][2]. It is not believed to encode a functional protein in humans and is not known to have any therapeutic or biological target activity[1]. Pseudogenes typically arise through duplication or retrotransposition events and do not produce active gene products. MEIS3P2 has sequence similarity to functional MEIS family genes, which are transcription regulators involved in processes like embryonic development and patterning, but MEIS3P2 itself lacks evidence of protein-coding function or direct involvement in disease or pharmacological pathways[1][2]. For these reasons, it is not considered a druggable target, nor is it associated with interacting drugs, mechanisms of action, biomarkers, or safety concerns. Key points: - MEIS3P2 is a non-functional pseudogene, not a therapeutic or biological target[1][2]. - It should not be confused with functional MEIS family members (e.g., MEIS3, MEIS1), which do have well-established roles in transcription regulation and are studied as disease targets[4][6][7]. - There is nothing to support active involvement in biological functions, disease roles, or pharmacological intervention. If a true homeobox MEIS family member is intended, such as MEIS3 or MEIS1, those are separate, functional transcription factors with relevant roles in development and disease[4][6][7].

Other names

Putative homeobox protein Meis3-like 2Meis1 homolog 3 pseudogene 2MEIS3P2putative homeobox protein Meis3-like 2