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Target intelligence / Profile preview
Melan-A Antigen (MART-1)
- Target
- MART-1
- Molecular classification
- Transmembrane protein, Melanocyte differentiation antigen
01
Overview
Melan-A, also known as MART-1, is a transmembrane protein and a melanocyte differentiation antigen. It is expressed in normal melanocytes, retina, and most melanocytic tumors. A peptide fragment from Melan-A can be presented by MHC class I molecules to cytotoxic CD8+ T lymphocytes, making it an important target for immune recognition in melanoma and a model antigen for studying T-cell responses. It is used as a diagnostic marker for melanocytic lesions and is being investigated as a target for cancer vaccines.
- Other names
- MART1MLANA
02
Mechanism of action
Melan-A peptides can be targets for cancer vaccines against melanoma.
03
Biological functions
Antigen presentationImmune recognition
04
Disease associations
Cancer
05
Biomarkers
Melan-A expression as a diagnostic marker for melanocytic lesions
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