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Target intelligence / Profile preview
Melanin-Concentrating Hormone Receptor 1 (MCHR1)
- Target
- MCHR1
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Melanin-concentrating hormone receptor 1 (MCHR1) is a class A G protein-coupled receptor that binds melanin-concentrating hormone (MCH). It is involved in regulating feeding behavior, energy homeostasis, sleep-wake cycles, mood, and reproductive functions, making it a potential therapeutic target for obesity, sleep disorders, and psychiatric conditions. Antagonists are being explored for appetite suppression and mood disorder treatment.
- Other names
- GPR24MCH-R1MCH-1RMCH1RSLC-1SLC1Somatostatin receptor-like
02
Mechanism of action
Antagonists block the action of endogenous MCH at the MCHR1 receptor site; Agonists stimulate MCHR1
03
Biological functions
Regulation of feeding behaviorAppetite controlEnergy homeostasisRegulation of sleep-wake cyclesMood regulationStress responseAnxiety regulationReproductive functionMaternal behavior
04
Disease associations
ObesityAppetite disordersSleep disordersAnxietyDepressionPsychiatric disorders
05
Safety considerations
Potential for off-target effects due to GPCR structural similarities.Careful monitoring of metabolic parameters is necessary when manipulating appetite and energy balance.
06
Interacting drugs
S36057
9 more in the full profile.
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