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Target intelligence / Profile preview
Melanocortin 3 Receptor (MC3R)
- Target
- MC3R
- Molecular classification
- G-protein coupled receptor (GPCR), Melanocortin receptor family
01
Overview
The melanocortin 3 receptor (MC3R) is a G-protein coupled receptor primarily expressed in the central nervous system, especially the hypothalamus. It plays a critical role in regulating energy balance, influencing appetite/hunger mechanisms, nutrient partitioning, growth, and puberty. Variants in MC3R are associated with obesity, delayed puberty, and disrupted circadian rhythms. It also has a role in anti-inflammatory processes.
02
Mechanism of action
Agonists activate Gs protein, leading to increased adenylate cyclase activity and cAMP production.
03
Biological functions
Signal transductionRegulation of appetite/hunger balanceNutrient partitioningRegulation of energy homeostasisRegulation of growth and pubertal timingRegulation of circadian rhythm and feeding behaviorAnti-inflammatory processes
04
Disease associations
Obesity susceptibilityGrowth disordersDelayed pubertyPulmonary tuberculosisArthritis
05
Safety considerations
Potential for disrupting energy balance and circadian rhythms.Side effects related to appetite regulation.
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