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Target intelligence / Profile preview
Melanocortin 5 Receptor (MC5R)
- Target
- MC5R
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
The melanocortin 5 receptor (MC5R) is a G protein-coupled receptor that binds melanocyte-stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH). It is expressed in a wide variety of tissues including exocrine glands, adrenal gland, and immune cells. MC5R plays a role in lipid metabolism, energy homeostasis, immunomodulation, thermoregulation and pheromone signaling. It is a potential therapeutic target for obesity, diabetes, and inflammatory diseases.
- Other names
- MC5RMC2
02
Mechanism of action
Agonism or antagonism of the melanocortin 5 receptor, modulating cAMP/PKA and PI3K-ERK signaling pathways.
03
Biological functions
Signal transductionLipid metabolism regulationEnergy homeostasisImmunomodulationThermoregulationRegulation of sexual behaviorPheromone signaling
04
Disease associations
ObesityDiabetes mellitusInflammatory diseases
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