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Target intelligence / Profile preview
Melanocortin Receptor Type 5 (MC5R)
- Target
- MC5R
- Molecular classification
- G protein-coupled receptor (GPCR)
01
Overview
Melanocortin receptor type 5 (MC5R) is a G protein-coupled receptor activated by melanocortin peptides derived from proopiomelanocortin (POMC). It is widely expressed in the central nervous system and peripheral tissues, including sebaceous glands, preputial glands, immune cells, skeletal muscle, and white adipose tissue. MC5R regulates lipid production, pheromone production, immunological responses, and energy metabolism. It has been implicated as a potential therapeutic target for obesity, diabetes mellitus, and disorders of exocrine gland function. MRAPs can regulate MC5R’s cell surface expression, dimerization status, pharmacology, trafficking within cells, ligand binding affinity/specificity, and signal transduction efficiency.
02
Mechanism of action
MC5R agonists promote cAMP/PKA, Ca²⁺, and PI3K–ERK1/2 signaling pathways.
03
Biological functions
Lipid metabolismLipolysisFatty acid oxidationGlucose uptakeExocrine secretionImmunomodulationInflammation controlPheromone signalingSexual behavior regulationEnergy homeostasis
04
Disease associations
ObesityDiabetes mellitus/type 2 diabetesDisorders of exocrine gland functionSkin conditions related to sebum production
05
Safety considerations
Altered social/sexual behaviorsEffects on pheromone signaling pathwaysDisruption of exocrine gland functionEffects on energy homeostasis
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