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Melanoma Antigen Family A Member 3
- Molecular classification
- Cancer-testis antigen
01
Overview
MAGE-A3 is a cancer-testis antigen frequently expressed in a variety of malignancies but with highly restricted expression in normal adult tissues. Its overexpression promotes cell proliferation and survival through mechanisms such as TP53 suppression. It serves as a prognostic marker and a target for immunotherapeutic strategies, including vaccines and engineered T-cell therapies.
- Other names
- MAGE-A3CT1.3HIP8HYPDMAGEA6
02
Mechanism of action
Targeted by therapeutic vaccines and engineered T-cell therapies (TCRs or CARs) specific for HLA-restricted epitopes derived from the antigen.
03
Biological functions
Cell proliferationCell survivalTP53 suppressionRegulation of transcription factors
04
Disease associations
Cancer
05
Safety considerations
Potential for cross-reactivity of anti-MAGE-A3 TCRs with peptides from closely related proteins (e.g., EPS8L2, MAGE-A12).Variable clinical efficacy of vaccines targeting MAGE-A3.
06
Biomarkers
MAGE-A3 expression level in tumor tissue
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