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Target intelligence / Profile preview
Melanoma Antigen Family A3 (MAGE-A3)
- Target
- MAGE-A3
- Molecular classification
- Cancer/testis antigen, Melanoma Antigen Gene family
01
Overview
MAGE-A3 is a cancer/testis antigen overexpressed in melanoma and other cancers. It is involved in embryogenesis, germ cell development, and apoptosis regulation. In tumors, its reactivation leads to protein expression that can be targeted by immune responses. It regulates E3 ubiquitin ligases like TRIM28, promoting cell proliferation, survival, and metastasis.
- Other names
- MAGEA3CTAGE1
02
Mechanism of action
Targeted by T-cell based immunotherapies, vaccines, and adoptive T-cell transfer therapies. Regulates E3 ubiquitin ligases like TRIM28 leading to degradation of tumor suppressors TP53 and AMPK. Promotes cell proliferation, survival (by repressing apoptosis), invasion/metastasis via epithelial-mesenchymal transition
03
Biological functions
Apoptosis regulationCell proliferationTumorigenesisE3 ubiquitin ligase regulation
04
Disease associations
MelanomaLung cancerBreast cancerOvarian cancer
05
Safety considerations
Potential off-target effects due to expression in testis
06
Biomarkers
MAGE-A3 expression level for prognosisAntibody titers against MAGE-A3
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