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Target intelligence / Profile preview
Melanoma Antigen Family C Member 1 (MAGEC1)
- Target
- MAGEC1
- Molecular classification
- Cancer/testis antigen, Tumor-associated antigen, Transcription factor
01
Overview
MAGEC1, also known as cancer/testis antigen 7.1 (CT7), is a protein-coding gene and member of the melanoma antigen gene (MAGE) family. It is expressed in a significant proportion of tumors across various histological types but is generally silent in normal tissues except for the testis, making it an attractive target for cancer immunotherapy.
- Other names
- CT7CT7.1Cancer/testis antigen 7.1Melanoma-associated antigen C1
02
Mechanism of action
MAGEC1 antagonists are under investigation to inhibit activity of the MAGEC1 protein.
03
Biological functions
Transcriptional regulationTumorigenesisOther
04
Disease associations
MelanomaUterine adnexa cancerCancer
05
Safety considerations
Potential for off-target effects due to expression in normal testis tissueImmune-related adverse events associated with immunotherapy
06
Biomarkers
MAGEC1 expression levels
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