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Target intelligence / Profile preview
Melanoma Antigen Family C2 (MAGEC2)
- Target
- MAGEC2
- Molecular classification
- Cancer/Testis Antigen
01
Overview
Melanoma Antigen Family C2 (MAGEC2) is a cancer/testis antigen that is normally expressed only in testis but is aberrantly expressed in various tumors, including melanoma and hepatocellular carcinoma. It enhances ubiquitin ligase activity and promotes tumor growth and invasion, making it a potential target for cancer immunotherapy.
- Other names
- CT10HCA587MAGEE1Cancer/testis antigen 10Hepatocellular cancer antigen 587Hepatocellular carcinoma-associated antigen 587
02
Mechanism of action
Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
03
Biological functions
Ubiquitin ligase enhancementCell cycle progressionTumor growth promotionInvasion promotionDNA damage repair
04
Disease associations
MelanomaHepatocellular carcinomaCancer
05
Safety considerations
Potential for off-target effects due to expression in normal testis tissue.
06
Biomarkers
MAGEC2 expression levels in tumors
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