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Target intelligence / Profile preview
Melanoma Antigen Gene 1 (None)
- Target
- None
- Molecular classification
- Cancer-testis antigen, Transcription factor
01
Overview
Melanoma Antigen Gene 1 (MAGEA1) is a cancer-testis antigen normally expressed only in testicular tissue but aberrantly activated in various cancers. It functions as a transcriptional repressor and promotes tumorigenesis by inhibiting or degrading p53. MAGE-A1-derived peptides can serve as epitopes for T-cell recognition, making it a target for cancer immunotherapy.
- Other names
- MAGEA1CT1.1Melanoma-associated antigen 1MAGE family member A1
02
Mechanism of action
Inhibition/degradation/inactivation of p53
03
Biological functions
Transcriptional repressionNegative regulation of Notch signalingRegulation of gene expressionTumorigenesis
04
Disease associations
CancerDyskeratosis congenita
05
Safety considerations
Potential for off-target effects due to homology with other MAGE family membersImmune-related adverse events in immunotherapy
06
Biomarkers
MAGE-A1 expression in tumor tissue
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