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Target intelligence / Profile preview
Melanoma antigen gene A1 (MAGEA1)
- Target
- MAGEA1
- Molecular classification
- Cancer/Testis Antigen (CTA), Transcription factor
01
Overview
MAGEA1 is a member of the MAGEA gene family and is classified as a cancer/testis antigen (CTA). It is normally expressed in the testis but is aberrantly expressed in various tumors, making it an attractive target for cancer immunotherapy. MAGEA1 functions as a transcriptional repressor and interacts with histone deacetylases, influencing gene expression and chromatin structure. It also plays a role in the Notch signaling pathway and is involved in multiprotein complexes, such as the TRIM31-MAGEA1-NSE4 complex, suggesting roles in ubiquitination pathways. Its immunogenic epitopes are recognized by cytotoxic T lymphocytes, which is exploited in immunotherapeutic approaches.
- Other names
- CT1.1MAGE1MAGE family member A1
02
Mechanism of action
N/A
03
Biological functions
Transcriptional repressionHistone deacetylase bindingNegative regulation of Notch signaling pathwayRegulation of chromatin structure
04
Disease associations
CancerDyskeratosis congenita
05
Safety considerations
Off-target effects due to expression in normal testisPotential for immune-related adverse events in immunotherapy
06
Biomarkers
MAGEA1 expression in tumor tissue
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