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Target intelligence / Profile preview
Melanoma Antigen Gene Family A Member 3 (None)
- Target
- None
- Molecular classification
- Cancer-testis antigen, Type I MAGE family, Protein
01
Overview
Melanoma antigen gene family A member 3 (MAGEA3) is a cancer-testis antigen normally expressed in reproductive tissues but aberrantly re-expressed in various cancers, including melanoma and non-small cell lung cancer. It interacts with STAT1 and modulates the AMPK/mTOR pathway, promoting cell viability and tumor growth. MAGE-A3 elicits immune responses and is a target for cancer vaccines and PROTAC-based therapies.
- Other names
- MAGE-3MAGEA3CT1.3HIP8HYPDMAGEA6
02
Mechanism of action
PROTACs (proteolysis-targeting chimeras) induce targeted degradation of the protein
03
Biological functions
Promotes cell viabilityRegulates STAT1/pYSTAT1 levelsModulates AMPK/mTOR signalingSubstrate recognition for E3 ligase complexesRegulation of proteostasis
04
Disease associations
Cancer
05
Safety considerations
Mixed clinical trial results for vaccines targeting MAGE-A3Potential for off-target effects due to sequence similarity with other MAGE family membersComplexity of the MAGE-A3/TRIM28/AMPK/mTOR pathway
06
Biomarkers
MAGE-A3 expression level in tumor tissue
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