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Target intelligence / Profile preview
Melanoma-Associated Antigen (MAA)
- Target
- MAA
- Molecular classification
- Proteoglycan, Glycoprotein, Enzyme, Antigen
01
Overview
Melanoma-associated antigens (MAAs) are a group of proteins and glycoproteins that are preferentially or exclusively expressed in melanoma cells, with limited expression in normal tissues. These antigens serve as important biomarkers for melanoma diagnosis and as targets for immunotherapy due to their tumor-specific expression patterns.
- Other names
- HMW-MAACSPG4p97MelanotransferrinTyrosinaseMelan-A/MART-1MAGEs
02
Mechanism of action
Redirects immune responses specifically toward tumor cells expressing these antigens.
03
Biological functions
Cell adhesionCell migrationMelanin biosynthesisImmune responseIron transportTumor markerEmbryogenesisGerm cell developmentApoptosis
04
Disease associations
CancerMelanoma
05
Safety considerations
Off-target effects on healthy tissuePotential for immune-related adverse events
06
Interacting drugs
Anti-HMW-MAA antibodies
3 more in the full profile.
07
Biomarkers
HMW-MAA expressionCSPG4 expressionp97 expressionTyrosinase expressionMelan-A/MART-1 expression
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