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Target intelligence / Profile preview
Melanoma-associated antigen 1 (MAGEA1)
- Target
- MAGEA1
- Molecular classification
- Melanoma Antigen Gene (MAGE), Transcription factor
01
Overview
Melanoma-associated antigen 1 (MAGEA1) is a member of the MAGE-A subfamily of the MAGE family of proteins. It functions as a transcriptional repressor, interacting with Ski Interacting Protein and histone deacetylases. MAGEA1 is normally expressed in testis and placenta but is aberrantly expressed in various cancers, including melanoma, lung cancer, and esophageal cancer. Its tumor-specific expression and role in immune evasion make it a target for cancer immunotherapies.
- Other names
- MAGE1CT1.1
02
Mechanism of action
Enhances TRIM28/KAP1's ubiquitin ligase activity against p53, resulting in its degradation; binds to p53 DNA-binding domain directly which may prevent its transcriptional activity.
03
Biological functions
Transcriptional repressionImmune response
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects in normal tissues expressing MAGEA1 (e.g., testis, placenta)Immune-related adverse events due to T-cell activation against normal cells
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