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Target intelligence / Profile preview
Melanoma-associated antigen 2 (MAGEA2)
- Target
- MAGEA2
- Molecular classification
- Cancer-testis antigen, MAGE protein family, Transcription factor regulator
01
Overview
Melanoma-associated antigen 2 (MAGEA2) is a cancer-testis antigen frequently overexpressed across diverse malignancies. It acts primarily as an oncogenic factor via suppression/inhibition/degradation pathways targeting key tumor suppressors like TP53/p73—mainly through interactions involving E3 ubiquitin ligases and histone deacetylases—and represents both a biomarker and therapeutic target candidate for oncology research and clinical intervention.
- Other names
- MAGE 2
02
Mechanism of action
MAGEA2 acts primarily as an oncogenic factor via suppression/inhibition/degradation pathways targeting key tumor suppressors like TP53/p73—mainly through interactions involving E3 ubiquitin ligases and histone deacetylases.
03
Biological functions
Cell proliferationRegulation of p53 pathwayProtein ubiquitinationTumorigenesisRegulation of apoptosisImmune response
04
Disease associations
CancerMelanomaHead and neck squamous cell carcinoma (HNSCC)Breast cancerProstate cancerMultiple myeloma
05
Safety considerations
Potential for off-target effects due to sequence homology within the MAGE familyPossible immune-related adverse events in immunotherapy approaches
06
Biomarkers
Diagnostic/prognostic biomarker for certain cancersPredictive biomarker for response to immunotherapy
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