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Target intelligence / Profile preview
Melanoma-associated antigen 2 (MAGE-A2) peptide presented by Human Leukocyte Antigen A2 (HLA-A2) (MAGE-A2/HLA-A2 complex)
- Target
- MAGE-A2/HLA-A2 complex
- Molecular classification
- Peptide-MHC complex, Antigen
01
Overview
- Other names
- MAGE-A2/HLA-A*02:01MAGEA2-HLA-A2MAGE-2/HLA-A2MAGE-A2/HLA-A2 peptide complexMAGE-A2 (112-120)/HLA-A2MAGE-A2 (157-166)/HLA-A2
02
Mechanism of action
T-cell receptor (TCR) binding and activation of cytotoxic T lymphocytes (CTLs) to induce tumor cell lysis.
03
Biological functions
Immune recognitionAntigen presentationTumor progressionp53 inhibition
04
Disease associations
CancerMelanomaLung cancerProstate cancerBreast cancerHead and neck cancer
05
Safety considerations
Cross-reactivity with other MAGE-A family membersOff-target toxicityCytokine release syndrome (CRS)Neurotoxicity (observed in related MAGE-A3 trials)
06
Interacting drugs
TCR-T therapies (investigational)
2 more in the full profile.
07
Biomarkers
HLA-A*02:01 expressionMAGE-A2 mRNA expressionMAGE-A2 protein expression
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