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Target intelligence / Profile preview
Melanoma-associated antigen 3
- Molecular classification
- Cancer/testis antigen, MAGE family protein
01
Overview
Melanoma-associated antigen 3 (MAGE-A3) is a cancer/testis antigen expressed in germ cells and various cancers, but not in most normal tissues except testis. It functions as an activator for RING-type zinc finger-containing E3 ubiquitin-protein ligases and acts as a repressor of autophagy. Its restricted expression and immunogenicity make it an attractive target for cancer immunotherapy, particularly cancer vaccines. Expression levels may correlate with prognosis in certain cancers, but this can vary.
- Other names
- CT1.3HIP8HYPDMAGE3MAGEA6
02
Mechanism of action
MAGE-A3 cancer vaccines stimulate the immune system to target and kill cancer cells expressing MAGE-A3.
03
Biological functions
Ubiquitin ligase activationAutophagy repressionEnhances ubiquitin ligase activity of TRIM28Stimulates ubiquitination of p53/TP53 via TRIM28 interactionImmunogenic - recognized by autologous cytolytic T lymphocytes
04
Disease associations
CancerMelanomaNon-small cell lung cancer (NSCLC)GliomasHematologic malignancies
05
Safety considerations
Potential for off-target immune responses against normal tissues expressing MAGE-A3Variability in expression levels across different tumors and patients
06
Interacting drugs
MAGE-A3 cancer vaccines
07
Biomarkers
MAGE-A3 expression level in tumor tissue
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