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Melanoma-associated antigen 4
- Molecular classification
- Cancer/testis antigen, MAGE-A subfamily protein
01
Overview
Melanoma-associated antigen 4 (MAGEA4) is a protein encoded by the MAGEA4 gene. It belongs to the MAGE-A subfamily and is classified as a cancer/testis antigen. MAGEA4 is highly expressed in male germ line cells, placental tissue, and various tumor types. It plays a role in cell cycle regulation and inhibits p53-mediated apoptosis, contributing to tumor survival. It interacts with Gankyrin to inhibit carcinogenesis. MAGEA4 is a target for immunotherapy, with genetically modified T cells and vaccines under clinical investigation. Its expression level can also serve as a prognostic marker in certain cancers.
- Other names
- CT1.4MAGE-41MAGE-X2MAGE4MAGE4AMAGE4B
02
Mechanism of action
T-cell mediated cytotoxicity, Inhibition of Gankyrin-mediated carcinogenesis
03
Biological functions
Cell cycle regulationInhibition of p53-mediated apoptosisRegulation of cell proliferation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects in immunotherapy due to limited expression in normal tissuesTumor resistance to immunotherapy
06
Biomarkers
MAGEA4 expression level as prognostic marker in salivary gland carcinomas
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