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Target intelligence / Profile preview
Melanoma-associated antigen 8 (MAGEA8)
- Target
- MAGEA8
- Molecular classification
- Cancer/Testis Antigen, MAGE-A subfamily
01
Overview
Melanoma-associated antigen 8 (MAGEA8) is a member of the MAGEA gene family, encoding cancer/testis antigens. It is typically expressed in various tumors but silent in most normal tissues except testis and placenta. MAGEA8 is implicated in tumorigenesis and may play roles in embryonal development and tumor progression. It serves as a target for cancer immunotherapy due to its tumor-restricted expression.
02
Mechanism of action
Targeted by experimental immunotherapies such as peptide vaccines, DNA vaccines, dendritic cell therapies, and mRNA-based approaches.
03
Biological functions
Embryonal developmentTumor transformationTumor progression
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to expression in testis and placenta (though generally immune-privileged sites).
06
Biomarkers
MAGEA8 expression levels in tumor tissue
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