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Target intelligence / Profile preview
Melanoma-associated antigen A family member 6
- Molecular classification
- Cancer/Testis Antigen, MAGE Family Protein, Ubiquitin ligase component
01
Overview
Melanoma-associated antigen 6 (MAGEA6) is a cancer/testis antigen belonging to the MAGEA gene family. It is normally expressed in germ cells of the testis, but is aberrantly re-expressed in various cancers, including melanoma, head and neck squamous cell carcinoma, lung carcinoma, breast carcinoma and gastric cancer. MAGEA6 functions as a ubiquitin ligase that targets AMP-activated protein kinase (AMPK) for degradation, impacting cellular metabolism regulation and potentially promoting tumorigenesis. Due to its restricted expression profile, MAGEA6 is considered an attractive target for cancer immunotherapy.
- Other names
- MAGEA6MAGE-A6
02
Mechanism of action
MAGEA6 acts as an activator of ubiquitin ligase activity, specifically targeting AMPK for degradation, thereby suppressing AMPK-mediated apoptosis and promoting tumorigenesis.
03
Biological functions
Ubiquitin ligase activityRegulation of AMPKRegulation of cellular metabolismApoptosis modulation
04
Disease associations
CancerMelanomaHead and neck squamous cell carcinomaLung carcinomaBreast carcinomaGastric cancer
05
Safety considerations
Potential for off-target effects due to expression in normal testis tissue.Possible immune-related adverse events with immunotherapy.
06
Biomarkers
MAGEA6 expression level (prognostic and predictive)Peptides derived from MAGEA6 (for immunotherapy)
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