Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Melanoma-associated antigen A1 (MAGEA1)
- Target
- MAGEA1
- Molecular classification
- Cancer/testis antigen (CTA), Group I MAGE-A family
01
Overview
Melanoma-associated antigen A1 (MAGEA1) is a cancer-testis antigen expressed in various tumor types but largely absent from normal adult tissues except for the testis. Its immunogenicity makes it a target for cancer immunotherapies, particularly T-cell based therapies. MAGEA1 expression can also serve as a biomarker for prognosis and prediction of chemoresistance.
- Other names
- CT1.1MAGE1
02
Mechanism of action
TCR-modified T-cell transfer, Peptide vaccines, Fab-based chimeric receptor targeting HLA/MHC-peptide complex
03
Biological functions
EmbryogenesisGerm cell genesisApoptosisTumor promotionCell proliferation
04
Disease associations
Cancer
05
Safety considerations
Potential off-target effects due to limited normal tissue expression (testis)
06
Biomarkers
Prognosis in melanoma, lung/breast/head-neck carcinomas and gliomasPrediction of chemoresistance to taxane-based chemotherapy regimens in gastric cancers
Beyond the preview
Go deeper on Melanoma-associated antigen A1 (MAGEA1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Melanoma-associated antigen A1 (MAGEA1).