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Target intelligence / Profile preview
Melanoma-associated antigen A10
- Molecular classification
- Type I Cancer/Testis Antigen, Type I MAGE family
01
Overview
Melanoma-associated antigen A10 (MAGE-A10) is a cancer/testis antigen primarily localized in the nucleus. It is normally expressed in immune-privileged sites such as the testis and placenta, but becomes aberrantly upregulated in various human solid tumors, making it an attractive target for immunotherapy. Clinically, MAGE-A10 has been targeted by cancer vaccines and adoptive cell therapies, such as ADP-A2M10, demonstrating some disease stabilization in clinical trials. However, challenges remain due to overlapping antigen expression with related proteins and the need for multi-antigen strategies.
- Other names
- MAGE-A10MAGEA10
02
Mechanism of action
Engineered T-cells recognize HLA-A*02:01-restricted peptides from MAGE-A10, leading to targeted cytotoxicity of MAGE-A10 expressing cells.
03
Biological functions
Regulation of cellular processes within germ cells or tumor cellsTumorigenesis
04
Disease associations
MelanomaLung carcinomaBladder cancerEsophageal carcinomaHead and neck squamous cell carcinomaUrothelial carcinomaBreast carcinoma
05
Safety considerations
Off-target toxicity due to overlapping expression with other antigens (e.g., MAGE-A4)Limited efficacy as a single-antigen target
06
Biomarkers
MAGE-A10 expression in tumor tissueHLA-A*02:01 positivity
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