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Target intelligence / Profile preview
Melanoma-associated antigen A2
- Molecular classification
- Cancer-testis antigen
01
Overview
MAGEA2 is a cancer-testis antigen that modulates key tumor suppressor pathways by interacting with proteins such as p53 and p73. Its variable promoter regions allow differential regulation across tissues. It is considered a potential biomarker or therapeutic target due to its restricted normal tissue expression but high prevalence in certain tumors, including melanoma, triple-negative breast cancer, and head and neck squamous cell carcinoma.
- Other names
- MAGE-A2Melanoma antigen family A, 2
02
Biological functions
Regulation of transcriptionTumor suppression modulationE3 ubiquitin ligase activity enhancement (proposed)Cell proliferation
03
Disease associations
CancerDyskeratosis congenita
04
Safety considerations
Potential for off-target effects due to sequence similarity within the MAGEA familyTumor-specific expression may not be absolute, leading to potential toxicity in normal tissues
05
Biomarkers
MAGEA2 overexpression in melanomaMAGEA2 overexpression in triple-negative breast cancerMAGEA2 overexpression in head and neck squamous cell carcinoma
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