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Target intelligence / Profile preview
Melanoma-associated antigen A4
- Molecular classification
- Cancer/Testis Antigen Family, Protein
01
Overview
Melanoma-associated antigen A4 (MAGE-A4) is a protein encoded by the MAGEA4 gene. It belongs to the cancer/testis antigen (CTA) family and is aberrantly expressed in various tumors while having restricted expression in normal adult tissues. MAGE-A4 regulates cell proliferation, inhibits G1 arrest, and modulates the p53 pathway. Due to its expression profile and immunogenicity, it is an attractive target for cancer immunotherapy, with vaccines and adoptive T-cell therapies being developed.
- Other names
- MAGEA4CT1.4MAGE-41MAGE-X2MAGE4MAGE4AMAGE4B
02
Mechanism of action
Cancer vaccines targeting CD8+ cytotoxic T lymphocytes and CD4+ helper T cells; Genetically modified autologous T cells targeting MAGE-A4
03
Biological functions
Cell proliferationInhibition of G1 arrestModulation of p53 pathwayRegulation of cell cycle
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects in normal tissues expressing MAGE-A4 (e.g., testis).Immune-related adverse events associated with immunotherapy.
06
Biomarkers
MAGE-A4 expression levels
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