Target intelligence / Profile preview

Melanoma-associated antigen A9 (MAGEA9)

Target: MAGEA9
Molecular classification: Cancer-testis antigen

Overview

MAGEA9 is a member of the MAGE family of cancer-testis antigens, normally expressed in testis and placenta but frequently aberrantly expressed in a wide range of tumors. It contributes to stemness properties in liver cancer stem cells and is correlated with resistance to chemotherapy-induced apoptosis. Overexpression is associated with poor clinical outcomes, making it a potential prognostic biomarker and therapeutic target for cancer.

Other names: CT1.9MAGE9

Mechanism of action

Not applicable, MAGEA9 is a target.

Biological functions

Tumor progressionStemnessChemoresistanceImmune response

Disease associations

Cancer

Safety considerations

Potential for off-target effects due to expression in normal testis/placenta.Immunogenicity of cancer-testis antigens.Association with more aggressive tumor phenotypes and poor prognosis might complicate trial design and interpretation.

Interacting drugs

Gemcitabine (GEM)

3 more in the full profile.

Biomarkers

MAGEA9 expression level in tumor tissue

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