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Target intelligence / Profile preview
Melanoma-associated antigen A9 (MAGEA9)
- Target
- MAGEA9
- Molecular classification
- Cancer-testis antigen
01
Overview
MAGEA9 is a member of the MAGE family of cancer-testis antigens, normally expressed in testis and placenta but frequently aberrantly expressed in a wide range of tumors. It contributes to stemness properties in liver cancer stem cells and is correlated with resistance to chemotherapy-induced apoptosis. Overexpression is associated with poor clinical outcomes, making it a potential prognostic biomarker and therapeutic target for cancer.
- Other names
- CT1.9MAGE9
02
Mechanism of action
Not applicable, MAGEA9 is a target.
03
Biological functions
Tumor progressionStemnessChemoresistanceImmune response
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to expression in normal testis/placenta.Immunogenicity of cancer-testis antigens.Association with more aggressive tumor phenotypes and poor prognosis might complicate trial design and interpretation.
06
Interacting drugs
Gemcitabine (GEM)
3 more in the full profile.
07
Biomarkers
MAGEA9 expression level in tumor tissue
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