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Target intelligence / Profile preview
Melanoma-associated antigen C2 (MAGEC2)
- Target
- MAGEC2
- Molecular classification
- Cancer-testis antigen (CTA), Type I MAGE family member, Oncogene
01
Overview
Melanoma-associated antigen C2 (MAGEC2) is a cancer-testis antigen belonging to the MAGE family. It is normally expressed only in testis but is aberrantly expressed in various tumors. MAGEC2 functions as an oncogene, promoting proliferation, survival, and EMT, and plays a role in DNA repair. It is considered a potential target for cancer immunotherapy.
- Other names
- CT10HCA587MAGEE1Cancer/testis antigen 10Hepatocellular carcinoma-associated antigen 587
02
Biological functions
Cell proliferationTumor growthTumor survivalEpithelial-mesenchymal transition (EMT)DNA repairSTAT3 activationCell cycle regulation
03
Disease associations
MelanomaLymphomaPancreatic cancerBreast cancerProstate cancerMammary gland cancerNon-small cell lung cancerLiver cancer
04
Safety considerations
Restricted expression pattern (testis only in normal tissues) allows for targeted immunotherapy, but potential for off-target effects should be considered.Associated with aggressive disease features (increased proliferation, chemoresistance, metastasis).
05
Biomarkers
Prognosis in breast cancerRecurrence risk in prostate cancer
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