Melanoma-associated antigen family A5 pseudogene (MAGEA5P)

Melanoma-associated antigen family A5 pseudogene (MAGEA5P) is a member of the MAGEA gene family located on chromosome Xq28. Although listed alongside protein-coding cancer/testis antigens, MAGEA5P is classified as a pseudogene, meaning it does not produce a functional protein product. There is ambiguity in some databases and literature, with some records describing a truncated protein sequence; however, the current consensus and annotation indicate this locus is non-functional and not expressed as a protein in normal or tumor tissues[1][2][3]. As a pseudogene, MAGEA5P does not serve as a direct therapeutic target nor is it a relevant biomarker or functional participant in disease pathways. The MAGE family (especially other MAGE-A members) is strongly implicated in cancer immunity and cell regulation, but these functions are not attributed to MAGEA5P. Context and rationale: MAGEA5P is explicitly annotated as a *pseudogene*, meaning it does not encode a functional protein (though some sources historically listed a truncated protein hypothetically)[1]. No evidence exists of translation into a functional protein, no known biological or pathological functions, and no drugs known to interact with the gene product. Its family (MAGE-A) is highly relevant in cancer/testis antigens and cancer immunity, but not this specific pseudogene. “is_incorrect” is set to true because it is not a valid therapeutic target and is sometimes mistakenly treated as protein-coding or conflated with the functional MAGEA5 gene. If you are seeking a cancer/testis antigen target, MAGEA5 (the functional gene, not the pseudogene), or other MAGE-A family members such as MAGEA3 or MAGEA4, may be more relevant. Key facts supported by sources: – MAGEA5P is a pseudogene, does not code for a protein, and has no direct target function[1][2][3][4].

Other names

MAGEA5PPutative melanoma-associated antigen 5PMAGE5MAGEA5CT1.5MGC129526Cancer/testis antigen 1.5MAGE family member A5 pseudogeneMAGE-5 antigenMAGE-5a antigenMAGE-5b antigencancer/testis antigen family 1 member 5