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Target intelligence / Profile preview
Melanoma-associated antigen family member A10 (MAGEA10)
- Target
- MAGEA10
- Molecular classification
- Cancer-testis antigen, MAGE family protein
01
Overview
Melanoma-associated antigen family member A10 (MAGEA10) is a cancer-testis antigen that is normally expressed in the testis and placenta but is aberrantly upregulated in a variety of tumors, including melanoma, lung cancer, and bladder cancer. MAGEA10 is considered a potential therapeutic target for cancer immunotherapy and a biomarker for certain malignancies. Its precise function remains unclear, but it may play a role in cell cycle regulation or apoptosis.
- Other names
- Melanoma-associated antigen 10MAGAA
02
Mechanism of action
TCR-T cell therapy; Cancer vaccines
03
Biological functions
Cell cycle regulation (potential)Apoptosis (potential)Oncogenesis (related to aberrant expression)
04
Disease associations
CancerMelanomaLung carcinomaUrothelial carcinomaHead and neck squamous cell carcinomaBreast carcinomaBladder cancerEsophageal carcinomaOvarian cancer
05
Safety considerations
Potential for off-target toxicity due to overlapping expression with other MAGE antigensDevelopment of resistance
06
Biomarkers
MAGEA10 expression level in tumor tissue
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