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Target intelligence / Profile preview
Melanoma-associated antigen MART-1 (MART-1)
- Target
- MART-1
- Molecular classification
- Transmembrane protein, Melanocyte differentiation antigen
01
Overview
Melanoma-associated antigen MART-1 (Melan-A) is a melanocyte lineage-specific protein antigen expressed on normal melanocytes and melanoma cells. It plays a crucial role in melanosome biogenesis and serves as a target antigen for cytotoxic T lymphocytes, making it a valuable target for melanoma immunotherapy. It is also used as a diagnostic marker for melanocytic tumors.
- Other names
- Melan-AMLANA
02
Mechanism of action
MART-1 peptides are presented on MHC molecules and recognized by cytotoxic T lymphocytes, leading to targeted cell death of melanoma cells.
03
Biological functions
PMEL processing and stabilityMelanosome biogenesisAntigen presentation
04
Disease associations
MelanomaCancer
05
Safety considerations
Potential for off-target toxicity in melanocytes (immunotherapy)Autoimmune reactions (immunotherapy)
06
Biomarkers
MART-1 expression in tumor tissue (diagnostic)MART-1 peptide-specific T cell responses (immunotherapy monitoring)
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